Increased mRNA for CD63 Antigen in Atherosclerotic Lesions of Watanabe Heritable Hyperlipidemic Rabbits.
نویسندگان
چکیده
منابع مشابه
Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
By screening a cDNA library constructed from aortic total RNA derived from Watanabe heritable hyperlipidemic (WHHL) rabbits by differential hybridization, we have obtained a cDNA encoding the kappa light chain of immunoglobulin. Northern blot analysis of total RNA prepared from aortas of WHHL and normal rabbits of various ages revealed that this light-chain mRNA accumulates gradually with age i...
متن کاملLocalization and smooth muscle cell composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits.
Morphological techniques (histology and electron microscopy), as well as immunofluorescence assays, were applied to the study of the localization and smooth muscle cell (SMC) composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic (WHHL) rabbits during a 4.5-month period. Vascular segments from different arteries (carotid, coronary, and iliac arteries) or from the same vesse...
متن کاملIncreased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
A novel lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) was recently identified in bovine aortic endothelial cells. It is strongly suggested to have a potential role in the initiation and development of atherosclerosis. In this study, we have isolated cDNA clones encoding the rabbit homologue of LOX-1 by screening a rabbit placenta cDNA library. In amino acid sequence and domain...
متن کاملAngiotensin II Destabilizes Coronary Plaques in Watanabe Heritable Hyperlipidemic Rabbits.
OBJECTIVE Increased plasma concentrations of angiotensin II (Ang II) have been implicated in many cardiovascular diseases, such as atherosclerosis, aortic aneurysms, and myocardial infarction, in humans. However, it is not known whether high levels of plasma Ang II affect coronary plaque stability and subsequent myocardial infarction. This study was designed to examine whether elevated plasma A...
متن کاملDecreased coronary vascular reserve in Watanabe heritable hyperlipidemic rabbits.
Watanabe heritable hyperlipidemic (WHHL) rabbits have severe hypercholesterolemia due to a genetic defect in their low density lipoprotein receptors. Therefore, they develop severe premature atherosclerosis of the large arteries including the coronary arteries. In the present study, we measured the coronary vascular reserve of these rabbits to evaluate the total cross-sectional coronary surface...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 1994
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.19.219